Table 1.
Molecular mass | 50 kDa (human VDR) |
Kd | |
1,25-(OH)2D | 10−10m |
25-OHD | 10−8m |
Isoelectric point | 6.2 |
Tissue concentration | 0.01–1 pmol/mg protein |
200–25,000 copies/cell | |
Structural variants | |
VDR-A (f-allele) | 427 Amino acids |
VDR-A (F-allele) | 424 Amino acids, by alternative translation start site |
VDR-B1 | 477 Amino acids, by N-terminal extension |
Polymorphisms | |
Large number in 5′ promoter | cdx-2 |
N terminal | Fok I |
C terminal | BsmI, ApaI, TaqI, TruI, polyA microsatellite |