Fig 3 Subgroup analyses for reduction in risk of coronary heart disease in patients with familial hypercholesterolaemia by statin use in a time dependent analysis. Smoking, diabetes, and hypertension were compared based on having ever been present. LDL cholesterol concentration was split based on the median value, and HDL cholesterol level split based on normal laboratory values. Hazard ratio (95% CI) by statin use is shown on a logarithmic scale