Table 2.

 Effect of statin treatment on risk of coronary heart disease in patients with familial hypercholesterolaemia by sex

	Model I			Model II			Model III			Model IV
	Hazard ratio (95% CI)	P value		Hazard ratio (95% CI)	P value		Hazard ratio (95% CI)	P value		Hazard ratio (95% CI)	P value
All patients (n=1950)	0.24 (0.18 to 0.30)	<0.001		0.22 (0.17 to 0.28)	<0.001		0.20 (0.15 to 0.27)	<0.001		0.18 (0.13 to 0.25)	<0.001
Men (n=924)	0.20 (0.15 to 0.28)	<0.001		0.20 (0.14 to 0.28)	<0.001		0.16 (0.11 to 0.25)	<0.001		0.17 (0.11 to 0.26)	<0.001
Women (n=1026)	0.30 (0.20 to 0.43)	<0.001		0.25 (0.17 to 0.37)	<0.001		0.28 (0.18 to 0.43)	<0.001		0.21 (0.13 to 0.34)	<0.001

Model I=adjusted for sex and year of birth. Model II=adjusted for sex, year of birth, and smoking status. Model III=adjusted for sex, year of birth, and low density lipoprotein cholesterol concentration without statin treatment. Model IV=adjusted for sex, year of birth, smoking status, high density lipoprotein and low density lipoprotein cholesterol concentrations, diabetes, and hypertension.