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. Author manuscript; available in PMC: 2009 Oct 1.

Published in final edited form as: Free Radic Biol Med. 2008 May 28;45(7):943–949. doi: 10.1016/j.freeradbiomed.2008.05.015

Pharmacokinetics of MnTE-2-PyP⁵⁺ in plasma (A), liver (B), spleen (C), kidney (D), lung (E), heart (F) and brain (G). Levels of porphyrin are given in µg per mL of plasma or per g of wet tissue. Drug was given at a single intraperitoneal dose of 10 mg/kg to female B6C3F1 mice. Animals were anesthesized, perfused and organs excised. 2 mice were used per data point. Calibration curves were done in plasma and related organs. The known amounts of MnTE-2-PyP⁵⁺ were added into the plasma and organ homogenates; the rest of the procedure was identical to the one used for drug-treated mice.

Pharmacokinetics of MnTE-2-PyP⁵⁺ in plasma (A), liver (B), spleen (C), kidney (D), lung (E), heart (F) and brain (G). Levels of porphyrin are given in µg per mL of plasma or per g of wet tissue. Drug was given at a single intraperitoneal dose of 10 mg/kg to female B6C3F1 mice. Animals were anesthesized, perfused and organs excised. 2 mice were used per data point. Calibration curves were done in plasma and related organs. The known amounts of MnTE-2-PyP⁵⁺ were added into the plasma and organ homogenates; the rest of the procedure was identical to the one used for drug-treated mice.