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. Author manuscript; available in PMC: 2009 Feb 12.
Published in final edited form as: Cancer Cell. 2008 Aug 12;14(2):146–155. doi: 10.1016/j.ccr.2008.06.00

Figure 3. Genetic inactivation of Cdkn1b in AKT1-Tg mice results in the development of invasive prostate cancer.

Figure 3

(A) Prostatic intraepithelial neoplasia in a representative section from the VP of AKT1-Tg mouse (~52 weeks old). Scale bar, 100 μM

(B) Invasive prostate cancer in representative sections from AKT1-Tg/Cdkn1b+/−. Sections were stained with H&E. Scale bar, 100 μM

(C) VP from AKT1-Tg mice were stained with antibodies directed against p63. Scale bar, 100 μM

(D) VP from AKT1-Tg/Cdkn1b+/− mice were stained with antibodies directed against p63. Scale bar, 100 μM

(E) Summary of tumor incidence by age and genotype.