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. Author manuscript; available in PMC: 2008 Nov 17.
Published in final edited form as: Anesth Analg. 2008 Apr;106(4):1296–contents. doi: 10.1213/ane.0b013e318164f1e9

Figure 1. Behavioral signs of neuropathic pain accompanied CCI in rats.

Figure 1

Baseline TWL were obtained for all animals before surgery, and then again 3 and 7 days after the ligation. Note that CCI animals treated with saline exhibited thermal hyperalgesia as a behavioral sign of neuropathic pain as their withdrawal latencies significantly decreased on day 3 and especially day 7. In contrast, the TWL of midazolam-treated animals were not significantly different from baseline on either day 3 or 7. Note also that flumazenil co-administration prevented the anti-hyperalgesic effect of midazolam, but that flumazenil alone did not modify the CCI-elicited decreases in TWL. The withdrawal latencies are shown for the ipsilateral (operated) leg. Each group consisted of 8 animals. Error bars represent the SD; a=significantly different from baseline within that group; b=significantly different from midazolam-treated CCI rats on that day.