TABLE 1.
Summary of InBios Active TbDetect IgG ELISA, IBL M. tuberculosis IgG ELISA, and Anda Biologicals TB ELISA results to culture and/or ADD results in a healthy control group
| Assay and result or parameter | No. of samples with the following culture/ADD result:
|
% Agreement (95% CI) | % Sensitivity (95% CI) | % Specificity (95% CI) | |
|---|---|---|---|---|---|
| Positivea | Negativeb | ||||
| InBios Active TbDetect IgG ELISA | 96.2 (91.1-97.7) | 83.3 (68.6-87.8) | 98.9 (95.8-99.8) | ||
| Positive | 15 | 1 | |||
| Negative | 3 | 86 | |||
| Equivocal | 0 | 1 | |||
| Total | 18 | 88 | |||
| IBL M. tuberculosis IgG ELISA | 84.0 (82.5-84.0) | 5.6 (1.2-5.6) | 100.0 (99.1-100) | ||
| Positive | 1 | 0 | |||
| Negative | 17 | 88 | |||
| Equivocal | 0 | 0 | |||
| Total | 18 | 88 | |||
| Anda Biologicals TB ELISA | 74.2 (65.5-78.3) | 83.3 (63.5-94.0) | 72.0 (67.2-74.6) | ||
| Positive | 15 | 21 | |||
| Negative | 3 | 54 | |||
| Equivocal | 0 | 13 | |||
| Total | 18 | 88 | |||
a
Samples are positive by culture and/or ADD. The 18 positive samples are comprised of 12 that are confirmed serologically to be HIV negative and 6 that are serologically HIV positive.
b
Negative samples are from low-risk U.S.-born individuals (group I).