TABLE 2.
Main characteristics of M. leprae antigens tested in Brazila
| Gene | Functional classificationb | Protein type | Size (kDa) | M. tuberculosis homolog | % Identity with other mycobacterial homologs
|
||||
|---|---|---|---|---|---|---|---|---|---|
| M. tuberculosis homologs | M. bovis BCG homologs | M. avium homologs | M. marinum homologs | M. smegmatis homologs | |||||
| ML0276 | V | Hypothetical protein | 16.2 | Rv0390 | 79.0 | 78 | 71 | 70 | 68 |
| ML0316 | I.J.1 | Transcriptional regulator | 21.0 | Rv0067c | 68.8 | 38 | 31 | 39 | 58 |
| ML0398 | III.A | d-Ribose-binding protein | 36.9 | None | 0 | 0 | 0 | 0 | 29 |
| ML0541 | I.F.1 | Guanylate kinase | 22.6 | Rv1389 | 79.1 | 77 | 82 | 83 | 78 |
| ML0543 | I.B.7 | Flavoprotein | 44.2 | Rv1391 | 87.0 | 84 | 83 | 82 | 78 |
| ML0840 | VI | Hypothetical protein | 47.7 | None | 0 | 0 | 62 | 0 | 45 |
| ML1011 | VI | Hypothetical protein | 14.6 | None | 0 | 30 | 31 | 30 | 28 |
| ML1213 | II.C.4 | Conserved membrane protein | 80.1 | Rv1565c | 76.5 | 25 | 28 | 27 | 54 |
| ML1623 | III.B | Hsp90 family protein | 73.8 | Rv2299c | 80.8 | 77 | 77 | 77 | 0 |
| ML2044 | VI | Hypothetical protein | 7.9 | None | 0 | 29 | 62 | 29 | 37 |
| 46f (ML0405-ML0568) | Artificial chimeric fusion, hypothetical protein | 46 | |||||||
a
Annotations for gene names, functional classification, and proteins are according to the Sanger database.
b
I.B.7, miscellaneous oxidoreductases and oxygenases; I.F.1, purine ribonucleotide biosynthesis proteins; I.J.1, repressors/activators; II.C.4, conserved membrane proteins; III.A, transport/binding proteins; III.B, chaperones/heat shock proteins; V, conserved hypothetical proteins; VI, unknowns.