TABLE 2.
Diagnostic characteristics of EBV IgA-VCA, IgA-EBNA1, IgA-EA, and IgG-EA for the xMAP technology and ELISA for NPC patients (n = 135) and healthy controls (n = 130)
| Assay and EBV marker | AUC (95% CI) | Cutoff | Sensitivity (%) | Specificity (%) |
|---|---|---|---|---|
| xMAP | ||||
| IgA-VCA | 0.785 (0.730-0.841) | 700 (FI) | 76.3 | 71.5 |
| IgA-EBNA1 | 0.812 (0.760-0.864) | 6,000 (FI) | 74.1 | 75.4 |
| IgA-EA-D | 0.882 (0.843-0.922) | 500 (FI) | 79.3 | 81.8 |
| IgG-EA-D | 0.943 (0.916-0.970) | 1,000 (FI) | 87.4 | 90.0 |
| ELISA | ||||
| IgA-VCA | 0.946 (0.919-0.972) | 0.20 (OD) | 91.9 | 83.8 |
| IgA-EBNA1 | 0.863 (0.817-0.909) | 0.15 (OD) | 80.0 | 80.0 |
| IgA-EA-D | 0.960 (0.938-0.981) | 0.25 (OD) | 92.6 | 90.8 |
| IgG-EA-D | 0.926 (0.897-0.956) | 0.30 (OD) | 85.2 | 82.3 |