TABLE 3.

Correlation of bacteremia and ECL and PCR assay results with clinical score in the high-dose AGM cohort^a

Monkey	Dose, CFU/ml of blood (LD50)	Time		Bacteremia (CFU/ml)	ECL result (S/N value)		PCR result (CT)b		Clinical score
		Day	Hour		PA	Capsule	PA	Capsule
V537	1.6E + 07 (1,455)	−2	−48	0	0.99	1.08	BLD	BLD	NT
		0	7	0	0.98	BLD	BLD	BLD	NT
		1	24	0	1.00	1.17	BLD	BLD	NT
			36	0	1.15	1.18	33.92	BLD	NT
		2	48	940	67.76	43.19	28.70	28.85	0
			60	NT	NT	NT	NT	NT	NT
		3	72	>1,000	NT	NT	NT	NT	NT
			84c	NT	NT	NT	NT	NT	0
W164	1.9E + 07 (1,727)	−2	−48	0	0.96	0.90	BLD	BLD	NT
		0	7	0	0.97	NT	BLD	BLD	NT
		1	24	0	0.96	0.95	36.68	BLD	NT
			36	0	1.04	NT	BLD	BLD	NT
		2	48	>1,000	11.39	9.24	29.86	30.17	1
			60	900	50.75	26.96	28.69	29.63	1
		3	72	>1,000	68.43	20.43	27.45	27.50	3
			84c	>1,000	70.54	1.19	11.74	12.64	NT
V540	1.1E + 07 (1,000)	−2	−48	0	1.09	1.10	BLD	BLD	NT
		0	7	0	1.00	NT	BLD	BLD	NT
		1	24	0	1.04	NT	BLD	BLD	NT
			36	0	1.04	NT	BLD	BLD	NT
		2	48	0	1.11	1.05	BLD	BLD	0
			60	0	1.12	NT	BLD	BLD	0
		3	72	0	1.27	1.08	BLD	BLD	1
			84	260	2.92	2.48	36.10	35.91	0
		4	96	>1,000	223.83	1.82	23.90	22.73	0
		5	120c	NT	NT	NT	NT	NT	NT
V547	1.3E + 07 (1,182)	−2	−48	0	0.98	0.92	BLD	BLD	NT
		0	7	0	0.99	NT	BLD	BLD	NT
		1	24	0	0.99	NT	BLD	BLD	NT
			36	0	1.01	NT	BLD	BLD	NT
		2	48	0	1.02	0.87	BLD	BLD	0
			60	NT	NT	NT	NT	NT	0
		3	72	0	1.18	0.93	35.99	BLD	2
			84	60	3.62	4.23	34.44	37.49	0
		4	96	820	25.62	15.24	32.30	33.32	0
		5	120	10	NT	NT	NT	NT	NT
		6	144c	144	NT	NT	NT	NT	NT

^aValues in boldface are positive. BLD, below the LOD; NT, not tested.

^bFor PCR results, both markers must be present for a sample to be considered positive.

^cTime of death of the animal.