TABLE 1.
The distribution of NK cell subsets is altered during N. americanus infectiona
| NK cell marker | Mean ± SD for indicated group of patients from areas of endemicity
|
|||
|---|---|---|---|---|
| Absolute no. of cells/mm3
|
Frequency (%)
|
|||
| Egg negative | Egg positive | Egg negative | Egg positive | |
| CD56+ | 168.0 ± 32.5 | 389.4 ± 258.7† | 6.72 ± 1.3 | 14.3 ± 9.5† |
| CD56+ CD16+ | 58.0 ± 28.5 | 204.2 ± 65.3† | 34.5 ± 17.0 | 52.7 ± 16.9 |
| NKG2A+ | 122.5 ± 10.0 | 182.4 ± 68.1 | 72.2 ± 0.5 | 46.7 ± 17.6† |
| NKG2D+ | 157.5 ± 10.0 | 321.3 ± 46.3† | 93.1 ± 6.4 | 82.4 ± 11.9§ |
| NKp46+ | 23.7 ± 9.0 | 51.3 ± 18.9† | 14.1 ± 5.4 | 13.9 ± 4.9 |
| NKp80+ | 47.1 ± 17.3 | 96.9 ± 41.7† | 28.0 ± 10.3 | 24.9 ± 10.7 |
a
PBMCs were isolated and stained with various combinations of antibodies against the indicated NK cell markers. Data show the numbers or frequencies of cells expressing each marker for each patient group after gating on CD56+ CD3− lymphocytes. CD56+ cells were gated on CD3− lymphocytes only. † indicates a significant difference between egg-negative (n = 17) and egg-positive (n = 36) groups at a P value of 0.05 by Tukey's test; § indicates a significant difference between the same groups at a P value of 0.10.