TABLE 3.
Passive immunization of C.B-17-WT and C.B-17-SCID mice with MAb MoPn-23 to the C. trachomatis MoPn MOMPa
| Antibody | Serum neutralizing titerb
|
Median (range)c
|
||||
|---|---|---|---|---|---|---|
| Lung wt (g)
|
No. of IFU recovered/lungs (106)
|
|||||
| C.B-17-WT | C.B-17-SCID | C.B-17-WT | C.B-17-SCID | C.B-17-WT | C.B-17-SCID | |
| MoPn-23 | 6,250 | 6,250 | 0.21 (0.18-0.30)*† | 0.22 (0.16-0.31)* | 3.3 (0.1-47)*† | 9.7 (0.9-94)* |
| NL-IgG | 1,250 | <50 | 0.35 (0.28-0.52)‡ | 0.40 (0.32-0.58) | 22,969 (654-61,683)‡ | 15,651 (697-68,277) |
a
Mice were euthanized at day 10 postinfection.
b
The serum neutralizing titer measured at day 10 postinfection.
c
*, P < 0.05 by the Mann-Whitney U test compared to the mice inoculated with NL-IgG; †, P > 0.05 as determined by the Mann-Whitney U test compared to the C.B-17-SCID mice receiving MoPn MAb 23; ‡, P > 0.05 as determined by the Mann-Whitney U test compared to the C.B-17-SCID mice receiving NL-IgG.