FIG. 1.

Development of experimental Lyme arthritis in control C3H (wt) and C3H IL-10^−/− (IL-10 ko) mice following infection with B. burgdorferi. Ankle swelling was determined weekly as described in Materials and Methods and was compared to ankle diameter measurements taken immediately prior to infection. The data are pooled means ± standard errors from two separate experiments; n = 10. An asterisk indicates that the IL-10 ko value is significantly different from the wt value at the P < 0.001 level.