TABLE 1.
Mutations in the HA proteins of clones of MA A/HK/1/68 obtained after passages 12 (HKMA-12 to HKMA-12E) and 20 (HKMA-20 to HKMA-20E)
| Virus | Mutationa in indicated protein at indicated aa position
|
||||||
|---|---|---|---|---|---|---|---|
| HA1
|
HA2
|
||||||
| 2 | 162 | 218 | 246 | 154 | 156 | 158 | |
| HK wt | D | P | G | N | N | T | D |
| HKMA-12 | − | W | − | − | N | − | |
| HKMA-12A | Y | − | − | D | − | − | − |
| HKMA-12B | − | L | − | − | − | − | N |
| HKMA-12C | − | − | W | − | − | N | − |
| HKMA-12D | − | − | W | − | − | N | − |
| HKMA-12E | − | − | W | − | − | − | − |
| HKMA-20 | − | − | W | − | − | N | − |
| HKMA-20A | − | − | W | − | − | N | − |
| HKMA-20B | − | − | W | − | − | N | − |
| HKMA-20C | − | − | W | − | − | N | − |
| HKMA-20D | − | − | W | − | S | − | − |
| HKMA-20E | − | − | W | − | − | N | − |
a
− indicates identity with the parental sequence.