TABLE 1.
Invasion scores of mice inoculated with ED/Neo or ED/TSLC1 cells
| Cell line and mouse | Invasion score for organ by observation:
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Macroscopica
|
Microscopicb
|
|||||||||
| Liver | Kidney | Lung | Ovary | Spleen | Liver | Kidney | Lung | Ovary | Spleen | |
| ED/TSLC1 | ||||||||||
| T1 | 3+ | − | +/− | 1+ | − | 3+ | − | 2+ | 2+ | − |
| T2 | 3+ | − | − | 1+ | − | 3+ | − | 2+ | 2+ | − |
| T3 | 3+ | − | +/− | 2+ | − | 3+ | − | 2+ | 2+ | − |
| T4 | 3+ | − | − | 1+ | − | 3+ | − | 2+ | 2+ | − |
| T5 | 2+ | − | − | 2+ | − | 3+ | − | 2+ | 3+ | − |
| T6 | 3+ | − | +/− | 1+ | − | 3+ | − | +/− | 2+ | − |
| ED/Neo | ||||||||||
| N1 | − | − | − | 2+ | − | 2+ | − | +/− | 3+ | − |
| N2 | +/− | − | − | 1+ | − | +/− | − | − | 2+ | − |
| N3 | − | − | − | 2+ | − | − | − | +/− | 2+ | − |
| N4 | − | − | − | 1+ | − | − | − | − | 2+ | − |
| N5 | − | − | − | 1+ | − | NDc | ND | ND | ND | ND |
| N6 | − | − | − | 1+ | − | ND | ND | ND | ND | ND |
a
Subjective invasion scores by macroscopic observation were as follows: −, no invasion; +/−, less than 10% invasion in the organ; 1+, 10 to 30% invasion in the organ; 2+, 30 to 70% invasion in the organ; 3+, over 70% invasion in the organ.
b
Subjective invasion scores by microscopic observation were as follows: −, no invasion; +/−, less than 1% leukemia cells in the section; 1+, less than 10% leukemia cells in the section; 2+, 10 to 30% leukemia cells in the section; 3+, over 30% leukemia cells in the section
c
ND, not done.