TABLE 2.

Clinical characteristics of patients and pathological findings of organ invasion^a

Patient no.	Age (yr)/sex	Clinical characteristic				Invasion score in NOG miceb				TSLC1 expression scorec
		Diagnosis (ATL type)	WBC (109/liter)	Lymphocytes (%)	Atypical cells (%)	Liver	Lung	Spleen	Lymph node
1	73/M	Chronic	7.8	59	47	3+	3+	3+	ND	3+
2	59/F	Chronic	9.0	75	40	3+	2+	2+	1+	2+
3	66/F	Chronic	29.4	49	75	3+	3+	3+	ND	3+
4	44/F	Chronic	22.6	51	45	3+	2+	2+	2+	2+
5	43/F	Chronic	18.6	63	43	3+	3+	3+	ND	2+
6	54/M	Acute	192.8	65	91	1+	2+	ND	ND	1+
7	58/M	Acute	67.3	71	80	3+	3+	3+	ND	2+
8	65/F	Acute	29.4	25	60	3+	2+	ND	3+	3+
9	68/M	Acute	30.0	79	81	3+	1+	1+	2+	2+
10	66/F	Acute	10.2	38	51	3+	3+	3+	ND	3+

^aAbbreviations: M, male; F, female; WBC, white blood cells; ND, not done.

^bSubjective invasion scores were as follows; 0, no invasion; 1+, less than 10% leukemia cells in the section; 2+, 10 to 30% leukemia cells in the section; 3+, over 30% leukemia cells in the section.

^cSubjective scores of TSLC1 expression in pathological immunostaining were as follows; −, no staining; 1+, faint staining in less than 10% of invasive leukemia cells; 2+, weak to moderate staining in 30 to 70% of invasive leukemia cells; 3+, intense staining in more than 70% of invasive leukemia cells.