FIG. 4.

Sensitivity to CCR5 coreceptor inhibitors. Env-pseudotyped virus was used to infect U87.CD4.CCR5 cells in the presence of increasing concentrations of PSC-RANTES (A) or TAK779 (B). BaL, reference R5 Env. Data are the means ± standard errors of the IC₅₀ for each Env clone in two or three replicate experiments (as illustrated in Fig. S2 in the supplemental material), with the results for individual Env clones represented by filled symbols. The data in panels A and B at 4.10 years p.i. shown as filled circles are results for env clone 10-18, the env clone closest to the ancestor of those obtained at 5.67 years p.i. (Fig. 1), while the unfilled circles represent other env clones from this time point.