TABLE 1.

Site-by-site analysis of positive selection in gp120^a from year 4.10 p.i. to year 5.67 p.i.

Position	Residue		Region	Change(s)
	Original	Mutation
15	R	K	C1
16	W	G	C1
25		M	C1	Insertion
33	N	D	C1	No PNGS, PCTLep
65	V	A	C1
85	V	I	C1
138	T	D	V1	PNGS conserved
153		G	V1	Insertion
154		I	V1	Insertion
158	T	K	V1	Charge added
173	R	K	V2	Charge conserved
195	N		V2	No PNGS, insertion
261	R	K	C2	Charge conserved, PCTLep
308	P	L	V3	PCTLep
315	S	R	V3	Charge added
317	H	T	V3	PCTLep
318	I	M	V3	PCTLep
323	A	V	V3	PCTLep
324	F	Y	V3	PCTLep
336	Q	K	V3	Charge added, PCTLep
361	F	Y	C3
396	T	A	V4
397	Q	K	V4	Charge added
404	M	I	V4
405	F	N	V4
406	N		V4	PNGS shifted, deletion
407	S	G	V4
414	E	G	V4
472		T	V5	PNGS shifted, deletion
475	T	N	V5	PNGS added
477	V	T	V5

^aFifteen additional sites in gp41 showed evidence of positive selection. Seven of 15 sites in gp41 under positive selection were in PCTLep.