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. 2008 Sep;12(3):183–199. doi: 10.1089/omi.2008.0010

Table 2.

Synapomorphies of Leiomyoma Specimens in Comparison to Normal Specimens (GDS533)

A. Overexpressed synapomorphic genes:
D16469 ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 NS[1, 2]
U07139 CACNB3 calcium channel, voltage-dependent, beta 3 subunit NS[1], OE[2]
M11718 COL5A2 collagen, type V, alpha 2 NS[1, 2]
U18300 DDB2 damage-specific DNA binding protein 2, 48 kDa NS[1, 2]
D38550 E2F3 E2F transcription factor 3 NS[1, 2]
M34677 F8A1 coagulation factor VIII-associated (intronic transcript) 1 NS[1, 2]
D89289 FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) NS[1, 2]
D86962 GRB10 growth factor receptor-bound protein 10 NS[1, 2]
M32053 H19, imprinted maternally expressed untranslated mRNA NS[1, 2]
U07664 HLXB9 homeobox HB9 OE[1, 2]
D87452 IHPK1 inositol hexaphosphate kinase 1 NS[1, 2]
U51336 ITPK1 inositol 1,3,4-triphosphate 5/6 kinase NS[1, 2]
 ABA002365 KIAA0367 NS[1], OE[2]
D78611 MEST mesoderm specific transcript homolog (mouse) OE[1], NS[2]
U19718 MFAP2 microfibrillar-associated protein 2 NS[1, 2]
M55593 MMP2 matrix metallopeptidase 2 (gelatinase A, 72 kDa gelatinase, 72kDa type iV collagenase) OE[1, 2]
U79247 PCDH11X protocadherin 11 X-linked NS[1, 2]
L24559 POLA2 polymerase (DNA directed), alpha 2 (70 kDa subunit) NS[1, 2]
M65066 PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, NS[1, 2]
D14694 PTDSS1 phosphatidylserine synthase 1 NS[1, 2]
U24186 RPA4 replication protein A4, 34 kDa NS[1, 2]
U85658 TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) NS[1, 2]
D82345 TMSL8 thymosin-like 8 NS[1, 2]
D85376 TRHR thyrotropin-releasing hormone receptor NS[1, 2]
D00596 TYMS* thymidylate synthetase OE[1, 2]
B. Underexpressed synapomorphic genes:
 X0330 ADH1B alcohol dehydrogenase IB (class I), beta polypeptide NS[1, 2]
M31994 ALDH1A1* aldehyde dehydrogenaes 1 family, member A1 UE[1], NS[2]
X05409 ALDH2* aldehyde dehydrogenase 2 family (mitochondrial) NS[1, 2]
L19871 ATF3* activating transcription factor 3 UE[1, 2]
U60521 CASP9 caspase 9, apoptosis-related cysteine peptidase NS[1, 2]
D49372 CCL11 chemokine (C—C motif) ligand 11 NS[1, 2]
X05323 CD200 molecule NS[1, 2]
M83667 CEBPD CCAAT/enhancer binding protein (C/EBP), delta NS[1, 2]
U90716 CXADR coxsackie virus and adenovirus receptor NS[1, 2]
M21186 CYBA cytochrome b-245, alpha polypeptide NS[1, 2]
U62015 CYR61* cysteine-rich, angiogenic inducer, 61 UE[1, 2]
Z22865 DPT dermatopontin NS[1, 2]
X56807 DSC2 desmocollin 2 NS[1, 2]
X68277 DUSP1* dual specificity phosphatase 1 UE[1, 2]
V01512 FOS* v-fos FBJ murine osteosarcoma viral oncogene homolog UE[1], NS[2]
L49169 FOSB FBJ murine osteosarcoma viral oncogene homolog B NS[1], UE[2]
L11238 GP5 glycoprotein V (platelet) NS[1, 2]
M36284 GYPC glycophorin C (Gerbich blood group) NS[1, 2]
M60750 HIST1H2BG histone cluster 1, H2bg NS[1, 2]
X79200 Homo spaiens mRNA for SYT-SSX protein NS[1, 2]
X92814 HRASLS3 HRAS-like suppressor 3 NS[1, 2]
M62831 IER2 immediate early response 2 NS[1, 2]
J04111 JUN* v-jun sarcoma virus 17 oncogene homolog (avian) UE[1, 2]
Y00503 KRT19* keratin 19 NS[1, 2]
X89430 MECP2 methyl CpG binding protein 2 (Rett syndrome) NS[1, 2]
U46499 MGST1 microsomal glutathione S-transferase 1 NS[1, 2]
M93221 MRC1 mannose receptor, C type 1 NS[1, 2]
M76732 MSX1* msh homeobox homolog 1 (Drosophila) NS[1, 2]
S71824 NCAM1 neural cell adhesion molecule 1 OE[1], NS[2]
X70218 PPP4C protein phosphatase 4 NS[1, 2]
U02680 PTK9 protein tyrosine kinase 9 NS[1, 2]
U79291 PTPN11 protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) NS[1, 2]
U77594 RARRES2* retinoic acid receptor responder (tazarotene induced) 2 NS[1, 2]
M11433, X07438 RBP1* retinol binding protein 1, cellular NS[1, 2]
L20859 SLC20A1 solute carrier family 20 (phosphate transporter), member 1 NS[1, 2]
M97935 STAT1 signal transducer and activator of transcription 1, 91kDa NS[1, 2]
J04152 TACSTD2 tumor-associated calcium signal transducer 2 NS[1, 2]
X14787 THBS1 thrombospondin 1 NS[1, 2]
U24488 TNXB* tenascin XB UE[1, 2]
Z29083 TPBG* trophoblast glycoprotein NS[1, 2]
X51521 VIL2 villin 2 (ezrin) UE[1], NS[2]
D87716 WDR43 WD repeat domain 43 NS[1, 2]
C. Dichotomously-expressed synapomorphic genes:
 ABCB1; ADRM1; AIM1; ALDH1A3; AMDD; ARHGEF6; ARL4D; ATP5B; Atp8a2; C1QB; CA9; CALM2; CTSB; CCRL2; CD52; CD99; CPA3; DPYD; DSG2; Emx2; FEZ2; FLNA; FOXO1A; FYN; GAPDH; GNB3; GSTZ1; H1F0; H2-ALPHA; HBG2; Ubx, Notch1; Hox5.4; HTR2C; ICA1; IGF2; INSR; ITGA6; ITGA9; KCNK1; KIAA0152; MAP1D; MATK; MBP; MDM4; MFAP5; MFI2 antigen p97; MLH1; MPZ; NDUFS1; NELL2; NNAT; NOS3; NR4A1; OASL; ODC1; OLFM1; PKN2; PON2; PRMT2; PSMC3; PTR2; RANBP2; RBMX; RDBP; RHOG; SAFB2; SCRIB; SELFP; SERPINF1; SMS; SPOCK2; ST3GAL1; THRA; TNXB; TTLL4; TXNIP; UPK2; XA; ZNF43

These comprise: 25 OE genes, 42 UE genes, and 79 DE genes. Asterisk (*) indicates a synapomorphy for leiomyosarcoma as well. Last column reports the status of the synapomorphies as described by [1] Hoffman et al. (2004) and [2] Quade et al. (2004) in their significant genes lists.