Table 6.
A List of 34 Synapomorphies Defining a Clade Composed of All Gastric Cancer Specimens (GDS1210)
| A. Overexpressed synapomorphic genes: | ||
| X81817 | BAP31 mRNA | No |
| D50914 | BOP1 block of proliferation 1 | No |
| X54667 | CST4: cystatin S MGC71923 | Yes |
| L17131 | HMGA1 high mobility group AT-hook 1 | No |
| D63874 | HMGB1 high-mobility group box 1 | No |
| D26600 | PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 | No |
| U36759 | PTCRA pre-T-cell antigen receptor alpha PT-ALPHA, PTA | No |
| X89750 | TGIF TGFB-induced factor (TALE family homeobox) | No |
| B. Underexpressed synapomorphic genes: | ||
| X76342 | ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide ADH-4 | No |
| M63962 | ATP4A ATPase, H+/K+ exchanging, alpha polypeptide ATP6A | No |
| M75110 | ATP4B ATPase, H+/K+ exchanging, beta polypeptide ATP6B | No |
| J05401 | CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) | No |
| L38025 | DNTFR ciliary neurotrophic factor receptor | No |
| M61855 | CYP2C9: cytochrome P450, family 2, subfamily C, polypeptide 9 CPC9 | No |
| D63479 | DGKD: diacylglycerol kinase, delta 130kDa DGKdelta, KIAA0145, dgkd-2 | No |
| X99101 | ESR2 estrogen receptor 2 (ER beta) | No |
| U21931 | FBP1 fructose-1, 6-bisphosphatase 1 | No |
| HG3432-HT3618_at | Fibroblast Growth Factor Receptor K-Sam, Alt. Splice 1 | No |
| M31328 | GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 | No |
| D42047 | GPD1L glycerol-3-phosphate dehydrogenase 1-like | No |
| M62628 | Human alpha-1 Ig germline C-region membrane-coding region, 3’end | No |
| D29675 | Human inducible nitric oxide synthase gene, promoter and exon 1 | No |
| M63154 | Human intrinsic factor mRNA | No |
| Z29074 | KRT9 keratin 9 (epidermolytic palmoplantar keratoderma) EPPK, K9 | No |
| X05997 | LIPF lipase, gastric | No |
| U50136 | LTC4S leukotriene C4 synthase MGC33147 | No |
| X76223 | MAL: mal, T-cell differentiation protein | No |
| U19948 | PDIA2 protein disulfide isomerase family A, member 2 | No |
| L07592 | PPARD peroxisome proliferative activated receptor, delta | No |
| U57094 | RAB27A, member RAS oncogene family | No |
| AC002077 | SLC38A3 solute carrier family 38, member 3 | No |
| Z29574 | TNFRSF17 tumor necrosis factor recepter superfamily, member 17 | No |
| C. Dichotomously expressed synapomorphic genes: | ||
| D00408 | CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7 CP37, P450-HFLA | No |
| U29092 | SELENBP1 selenium binding protein 1 | No |
Synapomorphies include: 8 OE genes, 24 UE genes, and 2 DE genes in comparison with the normal specimens. Last column reports the status of the synapomorphies as described by Hippo et al. (2002). Yes = listed; No = not listed.