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Comparison of the interactions of B-cell and T-cell superantigens. The Vβ region (yellow) of the TcR superimposed well on VH (cyan) of Fab 2A2 with an rmsd of 1.6 Å over 393 main-chain atoms. The T-cell superantigen, enterotoxin SEC3, (green) binds to the CDR1, CDR2, and HV4 loops of the Vβ region. SpA (red) binds at framework region 1 and 3, and the carboxyl-terminal portion of the CDR2 (including positions H57 and H59 in the C" strand) of the VH region.
