Table 1.
Sequences of human VH gene families at the positions involved in the interface with domain D
| H15 | H17 | H19 | H57 | H59 | H64 | H65 | H66 | H68 | H70 | H81 | H82a | H82b | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| VH1 (11) | G | S, T | K | T, A | Y | Q | G, D, E | R | T | T | E | S, R | S, R |
| VH2 (3) | T | T | T | K | Y | K | S, T | R | T | T, S | T | T | N |
| VH3 (22) | G | S | R, K | K, I, T | Y | K | G | R | T | S | Q | N, G | S |
| VH4 (11) | S | T | S | T | Y | K | S | R | T | S | K | S | S |
| VH5 (2) | G | S | K, R | T | Y | Q | G | Q, H | T | S | Q | S | S |
| VH6 (1) | S | T | S | N | Y | K | S | R | T | N | Q | N | S |
| VH7 (1) | G | S | K | P | Y | T | G | R | V | S | Q | C | S |
The numbers in parentheses for each VH group are the numbers of human germ-line V gene sequences reported in the V Base database (Medical Research Council, Centre for Protein Engineering). The VH3 family represents nearly half of all inherited human VH gene segments. Amino acids in italics are represented in less than 10% of functional inherited human genes.