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Alteration of redox homeostasis, redox signaling and cellular responses. Figure 9a: cells under physiological conditions in the absence of redox-dependent responses. Figure 9b: cells in which a significant level of intracellular ROS generation occurs as a moderate and transient change in redox state (b1), as a severe and irreversible change leading to cell death (b2) or as a chronic shift in redox state (b3).
