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Lactate dehydrogenase release (U/g dry wt) during 60 minutes of reperfusion, a marker of ischemic injury in age-matched non-diabetic (ND), Type 2 diabetic (BBZ), BBZ treated with aldose reductase inhibitor (BBZ-ARI), BBZ treated with sorbitol dehydrogenase inhibitor (BBZ-SDI) rat hearts. Diabetes duration of 12 weeks (n = 9) (A) and 48 weeks (n = 6) (B) were used in this study. Comparison of LDH release in 12 weeks diabetic and 48 weeks diabetic BBZ rat hearts (C).
