Table 4.

Cardiopulmonary effects of LCT and MCT/LCT in humans

A (LCT)
Author	Emulsion	Infusion rate	Patients	Results
Venus[11]	20% LCT	100 g/10 h	Sepsis Non-sepsis	↑ MPAP, ↑ Qs/Qt
Venus[12]	20% LCT	100 g/8 h	ARDS	↓ PaO2/FiO2 ↑ MPAP, ↑ Qs/Qt, ↑ PVR
Hwang[8]	10% LCT	50 g/4 h	Healthy ARDS Pneumonia COPD	↓ Qs/Qt, ↑ PaO2/FiO2 ↑ Qs/Qt, ↓ PaO2/FiO2 No changes No changes
Mathru[7]	20% LCT	100 g/10 h 100 g/5 h	ARDS ARDS	↑ Qs/Qt, =MPAP =Qs/Qt, ↑ MPAP
B (MCT/LCT)
Radermacher[13]	20% MCT/LCT	50 g/4 h	Sepsis	No changes
Fiaccadori[14]	20% MCT/LCT	3.3 mg/kg min	Heart surgery	No changes
Masclans[17]	20% LCT 20% MCT/LCT	2 mg/kg/min 12 h 2 mg/kg/min 12 h	ARDS ARDS	↑ CO No changes
Smyrniotis[18]	20% LCT 20% MCT/LCT	50% non-prot cal	Pancreatitis with ARDS	↑ MPAP, ↑ Qs/Qt, and ↓ PaO2/FiO2 ↑ VO2, ↑ CO
Chassard[19]	20% LCT 20% MCT/LCT	3 mg/kg/min 8 h 3 mg/Kg/min 8 h	Sepsis	No changes ↑ VO2
Faucher[20]	20% LCT 20% MCT/LCT	1 ml/kg/h 6 h 1 ml/kg/h 6 h	ARDS	↑ PaO2/FiO2, ↑ DO2
Lekka[16]	20% MCT/LCT Placebo		ARDS: lipids Placebo	↓ PaO2/FiO2, ↓ Comp, ↓ PVR

VO₂: oxygen consumption, Comp: compliance.