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. Author manuscript; available in PMC: 2008 Nov 17.
Published in final edited form as: Bioconjug Chem. 2007 Mar 2;18(3):903–911. doi: 10.1021/bc060250q

Scheme 2. Synthesis of peptidyl contrast agents.

Scheme 2

For clarity, 8a–9a and 8b–11b only show ligands coupled to the cyclen ring in a 1,4 configuration. However, a 1,7 configuration is also possible.