FIG. 4.

A: Glucose metabolism during saline and ghrelin administration in study 2. Hyperinsulinemic clamp. Glucose infusion rates and M value during saline and ghrelin administration. •, saline infusion; □, ghrelin infusion. B: Accumulative glucose infusion dosage during saline and ghrelin administration. The accumulative glucose dose was significantly decreased during the clamp period in the ghrelin study (P = 0.002). C: Glucose utilization during the terminal 30 min of basal and clamp periods in saline and ghrelin studies. Ghrelin did not significantly impact glucose metabolism in the basal period. During the clamp ghrelin infusion reduced the rates of oxidative, nonoxidative, and total glucose disposal (P = 0.009, P = 0.03, and P = 0.012, respectively). All data are presented as means ± SE.