TABLE 1.
Anthropometric and clinical data of the study population
| eGFR >90 ml/min per 1.73 m2 |
eGFR 60–90 ml/min per 1.73 m2 |
eGFR 30–60 ml/min per 1.73 m2 |
eGFR <30 ml/min per 1.73 m2 |
|||||
|---|---|---|---|---|---|---|---|---|
| Nondiabetic | Type 2 diabetic | Nondiabetic | Type 2 diabetic | Nondiabetic | Type 2 diabetic | Nondiabetic | Type 2 diabetic | |
| n (male/female) | 29 (23/6) | 24 (17/7) | 54 (29/25) | 36 (18/18) | 27 (9/18) | 11 (5/6) | 16 (11/5) | 33 (19/14) |
| Age (years) | 62 (51–95) | 63 (50–84) | 60 (50–79) | 65 (48–82) | 67 (22–76) | 67 (56–72) | 60 (43–78) | 67 (39–75) |
| BMI (kg/m2) | 24.5 (17.9–36.7) | 31.8 (20.7–56.9)* | 25.5 (20.9–41.5) | 31.4 (21.2–47.7)† | 24.5 (14.8–36.9) | 32.0 (21.0–43.4)‡ | 25.0 (18.2–35.6) | 25.9 (17.5–39.1) |
| SBP (mmHg) | 132 (100–181) | 138 (109–171) | 130 (95–160) | 140 (110–184) | 136 (88–198) | 134 (109–166) | 153 (109–182) | 139 (68–192) |
| DBP (mmHg) | 77 (57–107) | 80 (62–98) | 74 (47–100) | 80 (55–95)† | 74 (46–116) | 75 (56–108) | 88 (54–107) | 70 (37–102)§ |
| Cholesterol (mmol/l) | 5.2 (3.6–6.6) | 5.1 (3.1–7.3) | 5.3 (3.5–10.5) | 5.2 (2.4–8.7) | 5.2 (2.1–8.3) | 6.0 (3.4–8.2) | 4.0 (2.8–7.1) | 4.1 (1.7–7.5) |
| HDL cholesterol (mmol/l) | 1.4 (0.7–2.1) | 1.2 (0.6–2.3) | 1.5 (0.7–2.8) | 1.3 (0.8–2.0)† | 1.6 (0.8–2.9) | 1.1 (07–1.6)‡ | 1.0 (0.6–2.5) | 0.9 (0.5–2.3) |
| LDL cholesterol (mmol/l) | 3.4 (2.6–4.7) | 3.3 (1.7–4.6) | 3.4 (2.0–8.0) | 3.3 (1.0–5.5) | 3.5 (1.1–5.6) | 3.7 (2.1–5.9) | 2.3 (20–5.6) | 2.2 (1.1–3.9) |
| Triglycerides (mmol/l) | 1.5 (0.6–11.4) | 1.6 (0.7–5.9) | 1.1 (0.5–3.5) | 1.4 (0.5–12.2)† | 1.5 (0.5–4.7) | 2.6 (1.5–7.3)‡ | 1.7 (0.5–11.4) | 2.2 (0.8–7.8) |
| FBG (mmol/l) | 5.1 (3.5–8.9) | 6.3 (4.7–10.1)* | 5.1 (3.8–11.3) | 6.5 (2.7–10.1)† | 4.7 (3.4–7.3) | 7.1 (4.0–21.1)‡ | 5.0 (3.7–8.2) | 5.8 (4.0–21.7)§ |
| A1C (%) | 5.6 (4.6–6.6) | 6.0 (5.3–10.3)* | 5.5 (4.4–6.9) | 6.4 (5.1–9.6)† | 5.7 (4.2–7.4) | 6.6 (5.7–8.7)‡ | 5.6 (4.5–6.8) | 7.4 (5.3–8.8)§ |
| eGFR (ml/min per 1.73 m2) | 100 (90–126) | 100 (90–117) | 77 (60–89) | 76 (62–88) | 51 (30–59) | 46 (33–56) | 12 (3–29) | 9 (4–29) |
| TTR (μmol/l) | 4.72 (1.01–11.2) | 5.17 (1.94–12.1) | 5.31 (056–9.98) | 4.22 (0.61–9.03) | 4.44 (0.83–12.1) | 5.08 (1.81–6.85) | 4.20 (1.75–10.4) | 4.23 (0.65–9.74) |
Data are medians (range) unless otherwise indicated.
*
Significant difference, with P < 0.05, between type 2 diabetic and nondiabetic subjects with an eGFR >90 ml/min per 1.73 m2.
†
Significant difference, with P < 0.05, between type 2 diabetic and nondiabetic subjects with an eGFR 60–90 ml/min per 1.73 m2.
‡
Significant difference, with P < 0.05, between type 2 diabetic and nondiabetic subjects with an eGFR 30–60 ml/min per 1.73 m2.
§
Significant difference, with P < 0.05, between type 2 diabetic and nondiabetic subjects with an eGFR <30 ml/min per 1.73 m2. DBP, diastolic blood pressure; FBG, fasting blood glucose; SBP, systolic blood pressure; TTR, transthyretin.