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. Author manuscript; available in PMC: 2009 Dec 1.
Published in final edited form as: Psychopharmacology (Berl). 2008 Aug 19;201(2):203–218. doi: 10.1007/s00213-008-1268-7

Figure 2.

Figure 2

Dose- and time-response curves for 5-HTP-induced hypothermia. A range of doses of the serotonin precursor 5-HTP decreased temperature in SERT +/+ (a), +/− (b) and −/− (c) mice over time. Comparisons between the genotypes were made for temperature change 30 min after 5-HTP; SERT +/− mice administered 80 mg/kg 5-HTP, and SERT −/− mice administered 40, 80 and 160 mg/kg 5-HTP, had greater changes in temperature compared to SERT +/+ mice administered these same doses (d). Data represent the mean ± SEM. * p < 0.05 and **** p < 0.0001 compared to SERT +/+ mice administered the same dose of 5-HTP.