Skip to main content
. Author manuscript; available in PMC: 2009 Dec 1.
Published in final edited form as: Psychopharmacology (Berl). 2008 Aug 19;201(2):203–218. doi: 10.1007/s00213-008-1268-7

Figure 4.

Figure 4

Effects of pretreatment with WAY 100635 and SB 269970 on 5-HTP-induced temperature change. 5-HTP (80 mg/kg) again induced an exaggerated temperature change in SERT −/− mice 30 min after administration, with a trend toward significance in SERT +/− mice (p = 0.067) compared to SERT +/+ mice. Pretreatment with the 5-HT1A antagonist WAY 100635 (1 mg/kg) decreased 5-HTP-induced hypothermia in SERT +/+ and +/− mice, with no effect in SERT −/− mice. Conversely, in SERT −/− mice, pretreatment with the 5-HT7 antagonist SB 269970 (3 mg/kg) decreased the temperature change induced by 5-HTP, down to levels in SERT +/+ mice in the same drug condition, with a trend toward a decrease in SERT +/− mice (p = 0.094), whereas SB 269970 administered alone had no effect alone on 5-HTP-induced hypothermia in SERT +/+ mice. Pretreatment with the combination WAY 100635 (1 mg/kg) and SB 269970 (3 mg/kg) eliminated 5-HTP-induced hypothermia in SERT +/− and −/− mice, down to levels of their counterparts administered this combination of pretreatment drugs alone (i.e. in the absence of 5-HTP). Data represent the mean ± SEM. * p < 0.05, ** p < 0.01 compared to SERT +/+ mice in the same drug condition; ++ p < 0.01, ++++ p < 0.0001 compared to mice of the same genotype treated with the pretreatment drug(s) only; # p < 0.05, #### p < 0.0001 compared to mice of the same genotype administered vehicle plus 5-HTP.