Table 2.
Overall and individual serotonin syndrome behaviors in male and female SERT +/+, +/− and −/− mice administered 5-HTP (80 mg/kg)
| Sex
|
Two-way ANOVA
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Serotonin syndrome behavior(s)
|
Males
|
Females
|
Genotype
|
Sex
|
Interaction
|
|||||||
| SERT+/+
|
SERT+/−
|
SERT−/−
|
SERT+/+
|
SERT-+/−
|
SERT−/−
|
F2,31 |
p |
F1,31 |
p |
F2,31 |
p |
|
| Overall | 16.8±4.7 | 15.9±4.3 | 46.1±7.2 | 15.0±5.3 | 15.4±5.0 | 44.6±4.2 | 108.58 | <0.0001 | 0.42 | NS | 0.04 | NS |
| Headweaving | 7.3±1.3 | 7.2±2.7 | 15.2±2.7 | 7.5±2.7 | 8.2±3.8 | 15.6±5.4 | 17.66 | <0.0001 | 0.19 | NS | 0.04 | NS |
| Forepaw treading | 5.0±3.6 | 4.0±2.2 | 5.2±1.3 | 4.8±2.4 | 5.7±2.1 | 8.4±4.8 | 1.54 | NS | 2.09 | NS | 0.80 | NS |
| Backward movement | 0.0±0.0 | 0.2±0.4 | 2.4±0.9 | 0.3±0.5 | 0.0±0.0 | 1.6±0.1 | 6.88 | 0.004 | 0.24 | NS | 0.36 | NS |
| Hind limb abduction | 2.1±0.6 | 1.8±1.0 | 10.0±3.7 | 0.9±0.6 | 0.5±0.3 | 7.2±2.7 | 47.17 | −0.0001 | 6.23 | 0.02 | 0.50 | NS |
| Straub tail | 0.4±0.5 | 0.3±0.4 | 0.2±0.3 | 0.0±0.0 | 0.0±0.0 | 0.1±0.2 | 0.12 | NS | 4.96 | 0.04 | 0.50 | NS |
| Tremor | 0.5±0.4 | 0.6±0.4 | 2.6±1.9 | 0.1±0.3 | 0.0±0.0 | 2.4±1.4 | 15.94 | <0.0001 | 1.08 | NS | 0.10 | NS |
| Low posture | 1.5±0.4 | 1.9±0.4 | 10.5±2.3 | 1.5±0.6 | 1.1±0.7 | 9.3±1.6 | 155.86 | <0.0001 | 2.22 | NS | 0.55 | NS |
Data represent the mean ± SEM
NS not significant