. Author manuscript; available in PMC: 2009 Nov 1.

Published in final edited form as: J Autism Dev Disord. 2008 May 30;38(10):1966–1975. doi: 10.1007/s10803-008-0591-5

TABLE 1. Comparison of plasma metabolite concentrations in the transmethylation pathway between case and control parents.

Plasma Transmethylation Metabolites (Mean ± SD)	Control Mothers N=200	Case Mothers N=46	Case Fathers N=40
Methionine (μMol/L)	26 ± 4.7	23 ± 4.1	26 ± 5.5
SAM (nMol/L)	83 ± 14	78 ± 20	85 ± 16
SAH (nMol/L)	23 ± 8.1	33 ± 14^a	37 ± 15
% of subjects with SAH > 30 μMol/L	14.9%	54.3%^a	59%
SAM/SAH Ratio	4.0 ± 1.4	2.8 ± 1.6^a	2.7 ± 1.4
Homocysteine (μMol/L)	7.42 ± 1.7	9.8 ± 3.6^a	10.6 ± 2.5

P<0.001 Case vs. Control mothers