Figure 4.

Human β-globin mRNA expression in RBC of transplanted mice. Expression of human β-globin mRNA in RBC of recipient mice was quantified by RNase protection assay 1–9.5 mo posttransplantation. Expression levels of human β-globin mRNA are shown as a percentage of endogenous murine β-major mRNA levels and were corrected for the proportion of GFP-positive RBC based on the concordance between β-globin and GFP-expressing cells (see Fig. 5). Individual mice are represented by circles; mean expression values are indicated by horizontal lines.