Table 1. Medical History and Physical Examination.

	Number of patients	Percent of patients
Multiple gestation birth	8	32
Prenatal or perinatal complications	13	52
Cardiovascular abnormality	7	28
GI dysfunction	16	64
GI dysfunction other than reflux or constipation	5	20
Hematologic abnormality	2	8
Endocrine dysfunction	2	8
Renal dysfunction	2	8
Growth retardation (<2 SD for weight and/or height)	5	20
Microcephaly (<2 SD)	4	16
Macrocephaly (>3 SD)	4	16
Fatigability/exercise intolerance	17	68
Marked developmental gross motor delays *	8	32
Seizures	5	20
Movement disorders	2	8
Oculomotor abnormality	4	16
Ptosis	2	8
Sensorineural hearing deficit	3	12
Dysarthria	3	12
Multiple regressions	9	36
Regression(s) after three years of age	6	24
At least 1 major clinical finding uncommon in ASD **	24	96
At least 1 non-CNS organ system involved	21	84
At least 2 non-CNS organ systems involved	8	32
At least 1 neurologic finding uncommon in ASD †	15	60

^*Defined as ≥5 SD from mean age at walking [33].

^**Does not include multiple gestation birth, prenatal/perinatal complications, GERD, constipation or macrocephaly.

^†Does not include fatigability, non-refractory seizures, macrocephaly or regression.