Figure 1.

Ambulation (A and B), oxygen consumption (VO₂) (C and D), and carbon dioxide production (VCO₂) (E and F) were measured in MuPPARγKO (n = 4, gray circles) vs. Flox control (n = 4, black circles) siblings. Data were collected for 24 h of ad libitum food access (A, C, and E) followed by 24 h of fasting (B, D, and F). Ambulation was estimated by summing sequential beam interruptions measured independently in orthogonal horizontal directions. The diurnal dark period is indicated by the gray background. *, P < 0.05 for increased ambulation in MuPPARγKO mice compared with Flox siblings during the fasting dark period.