Table 1.
Effect of ROSI pretreatment on fatty acid and glucose energetics in skeletal muscle ex vivo
| 2-Br-palmitate uptake (relative units)
|
Palmitate oxidation (relative units)
|
||||
|---|---|---|---|---|---|
| Genotype | Treatment | Soleus | EDL | Soleus | EDL |
| n | 4–5 | 4–5 | 4–5 | 4–5 | |
| Flox | Vehicle | 1.00 | 0.68 ± 0.05 | 1.00 | 0.48 ± 0.14 |
| Flox | ROSI | 0.81 ± 0.14 | 0.68 ± 0.05 | 0.96 ± 0.20 | 0.63 ± 0.14 |
| n | 2 | 4–5 | 2–3 | 4–5 | |
| KO | Vehicle | 1.00 | 0.69 ± 0.07 | 1.00 | 0.99 ± 0.12 |
| KO | ROSI | 1.07 ± 0.01a | 0.54 ± 0.07 | 1.30 ± 1.01 | 1.09 ± 0.32 |
Uptake was studied in muscle isolated from mice on normal chow treated with ROSI or vehicle only by gavage for 5 d before study. Confidence limits represent standard errors of measurement. Relative units are in comparison with that measured in soleus of vehicle-treated animals.
a
P < 0.05 vs. vehicle, otherwise P value is nonsignificant for all ROSI vs. vehicle comparisons.