Table 1.

Blood data of 7-day-old pups

	NKCC2 genotype
	+/+	−/−
pH	7.49  ± 0.01	7.29  ± 0.04*
HCO3, mmol/liter	27.3  ± 1.0	13.3  ± 1.0*
Base excess, mmol/liter	3.2  ± 1.0	−11.8  ± 1.5*
Lactate, mmol/liter	2.6  ± 0.1	4.1  ± 0.2*
pCO2, mmHg	39.0  ± 1.5	27.3  ± 0.8*
Glucose, mg/dl	168.6  ± 9.7	81.0  ± 8.5†
Hematocrit, %	37.0  ± 0.5	46.6  ± 0.7†
Na, mmol/liter	131.9  ± 0.5	163.7  ± 3.6*
K, mmol/liter	6.1  ± 0.4	7.2  ± 0.1‡
Cl, mmol/liter	100.3  ± 1.1	117.0  ± 3.2*
Ca, mg/dl	10.7  ± 0.2	9.1  ± 0.7†
Mg, mg/dl	2.3  ± 0.04	3.1  ± 0.06*
Total protein, mg/dl	3.2  ± 0.1	3.9  ± 0.5†
Creatinine, mg/dl	0.35  ± 0.03	0.90  ± 0.17*
BUN, mg/dl	28.2  ± 3.3	194.3  ± 60.7*
PRC, ng Ang I/ml per h	127.6  ± 47.8	25,700  ± 1,840*

Data are means ± SEM. n > 6. pCO₂, CO₂ pressure; BUN, blood urea nitrogen; PRC, plasma renin concentration. 

*P vs. +/+ < 0.0001. 

^†P vs. +/+ < 0.005. 

^‡P vs. +/+ < 0.05.