Table 2.

Blood data of adult mice

	NKCC2 genotype
	+/+	−/−
pH	7.30  ± 0.01	7.42  ± 0.01*
HCO3, mmol/liter	24.5  ± 1.4	30.6  ± 1.3†
Base excess, mmol/liter	−2.5  ± 0.9	4.9  ± 0.6*
Lactate, mmol/liter	2.0  ± 0.4	2.2  ± 0.3
pCO2, mmHg	42.6  ± 3.6	48.2  ± 1.2
Glucose, mg/dl	199.6  ± 12.4	200.6  ± 11.6
Hematocrit, %	37.0  ± 3.2	70.0  ± 0.3*
Na, mmol/liter	145.2  ± 0.6	154.8  ± 2.9†
K, mmol/liter	5.8  ± 0.3	4.6  ± 0.1†
Ca, mg/dl	9.8  ± 0.7	9.1  ± 1.4
Creatinine, mg/dl	0.15  ± 0.05	0.23  ± 0.09
PRC, ng Ang I/ml per h	32.4  ± 5.0	751.3  ± 76.8‡

Mice were 3 months old and treated with indomethacin to 3 weeks of age. pCO₂, CO₂ pressure; PRC, plasma renin concentration. Data are means ± SEM. n > 5. 

*P vs. +/+ < 0.0005. 

^†P vs. +/+ < 0.05. 

^‡P vs. +/+ < 0.0001.