Table 3.

Water intake and urine excretion of adult mice

	NKCC2 genotype
	+/+	−/−
Water intake, ml/day	3.3  ± 0.2	13.2  ± 1.0*
Urine volume, ml/day	1.6  ± 0.2	10.0  ± 0.9*
Urine osmolality, mOsm	2,314  ± 74	371  ± 20*
Na, μmol/day	118.2  ± 19.8	119.4  ± 14.9
K, μmol/day	378.2  ± 14.4	415.3  ± 23.9
Cl, μmol/day	274.6  ± 23.4	301.4  ± 20.1
Ca, mg/day	0.12  ± 0.03	0.51  ± 0.08†
Mg, mg/day	0.31  ± 0.04	0.52  ± 0.19
Pi, mg/day	1.95  ± 0.11	3.39  ± 0.20†
Glucose, mg/day	0.55  ± 0.09	3.13  ± 0.83‡
Protein (males), mg/day	0.17  ± 0.03	10.10  ± 0.51*
Protein (females), mg/day	N.D.	2.68  ± 0.15*
PGE2, ng/day	4.0  ± 1.0	9.6  ± 1.2*

Mice were 3 months old and treated with indomethacin to 3 weeks of age. N.D., not detected (below detectable level). 

Data are means ± SEM. n > 5. 

*P vs. +/+ < 0.0001. 

^†P vs. +/+ < 0.001. 

^‡P vs. +/+ < 0.005.