Figure 9.

Effects of PRL and DEX on INS-1 cell fatty acid oxidation and esterification. INS-1 cells were incubated for 24 h in serum-free RPMI (11.1 mm glucose, 0.1% human serum albumin) in the presence or absence of rat PRL (20 nm), DEX (1 μm), a combination of the two, or diluent (control). Rates of ¹⁴C-palmitate oxidation and esterification were measured as described in Materials and Methods. Values, expressed as nanomoles per milligram protein per hour, represent the means ± se of all data from two independent experiments, each of which contained six wells per group. Statistically significant differences between the experimental (hormone treated) and control groups are indicated by asterisks. *, P < 0.05; **, P < 0.01; ***, P < 0.001.