Figure 6.

Summary of blue cone pattern analyses. (A) Average percentage of retinal regions having regular (blue columns) or random (red columns) patterns, as determined by NND analysis. Regions were scored as significantly regular or random based on the value of the conformity ratio.³² Proportions of regular versus random patterns were averaged over the number of retinas analyzed for each age, treatment, and genotype (two to five retinas in each case). Significant reductions in the percentage of regions showing locally regular patterns are indicated by blue brackets (*0.005 < P < 0.05 and **P < 0.005; Kolmogorov-Smirnov test). (B) Average percentage of retinal regions having regular (blue), random (red), or clumped (yellow) patterns as determined by quadrat analysis. Regions were scored as regular, random, or clumped based on the values of (var/mean)(N – 1).³³,³⁵ The different proportions of each pattern type (regular, random, or clumped) were averaged over the number of retinas analyzed for each age, treatment, and genotype (two to five retinas in each case). Significant reductions in the percentage of regions showing globally regular patterns are indicated by blue brackets (*0.005 < P < 0.05 and **P < 0.005; Kolmogorov-Smirnov test). Significant increases in the percentage of regions showing clumped patterns are indicated by yellow brackets (*0.005 < P < 0.05 and **P < 0.005; Kolmogorov-Smirnov test). (C) Mean (±SD) planimetric density of labeled blue cones. Significant differences are indicated by blue brackets (*P < 0.05; ANOVA and post hoc analysis).