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. Author manuscript; available in PMC: 2008 Nov 18.
Published in final edited form as: Chem Res Toxicol. 2005 Jul;18(7):1098–1107. doi: 10.1021/tx050023x

Scheme 1.

Scheme 1

A. Cytochrome P450-Mediated Epoxidation of Butadiene to Mono- and Di-Epoxides. B. Alkylation of Deoxyadenosine N1 by Cβ of Butadiene Mono-Epoxide (BDO) and Subsequent Deamination Yields the N1-(1-hydroxy-3-buten-2-yl)-2′-Deoxyinosine Adduct.