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CCR5 expression after brief exposure to RANTES analogs. Changes in CCR5 staining of activated primary CD4+ T cells after a 1-h. pulse with PSC-, 5P12-, 5P14-, or 6P4-RANTES. CCR5 was detected with PA12, a monoclonal Ab directed at the N terminus of CCR5 whose binding is not affected by exposure of the receptor to native or modified RANTES compounds. Error bars show ± SE for 6 replicate experiments with different CD4+ T cell donors.
