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Proposed structure–activity relationship for fully recombinant RANTES analogues. Our data suggest that the tetrapeptide Gln-Gly-Pro-Pro can provide a valid replacement for the PSC-moiety of PSC-RANTES (positions 0–3), provided that it is presented in the context of appropriate combinations of downstream structures at positions 4–9. These structures determine not only anti-HIV potency but G protein-linked signaling activity and capacity to induce intracellular receptor sequestration.
