Table 6.
Inhibition of chemotaxis by oleic acid without amplifiers of the chemoactic response
| Mean diameter ± SEM, cm | n | P | ||
|---|---|---|---|---|
| A. | Controls, mean of 2 | 6.06 ± 0.23 | 13 | — |
| Oleic 250 μM, mean of 2 | 4.86 ± 0.22 | 13 | 0.001 | |
| B. | Control | 5.75 ± 0.33 | 8 | — |
| Oleic, 250 μM | 4.22 ± 0.31 | 8 | 0.0004 | |
| Palmitic, 200 μM | 5.44 ± 0.38 | 8 | 0.29 |
A. In 81% plasma without EDTA or delipidated albumin, oleic acid significantly inhibited the chemotactic response. B. In 16% plasma to minimize the effects of endogenous fatty acids, oleic acid again significantly inhibited the chemotactic response; palmitic acid did not. Neither fatty acid affected the non-directed motile function of the PMN.