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Effects of internal ionizable groups on thermodynamic stability. (A–F) Thermodynamic stability (ΔG°H2O) of variants of SNase (light gray) or RNaseH (dark gray) with internal Lys at pH 10 (A), internal Glu at pH 5 (B), internal Asp at pH 5 (C), internal Lys at pH 7 (D), internal Glu at pH 7 (E), and internal Asp at pH 7 (F). (G and H) Ribbon diagram of SNase (G) (32) and RNaseH (H) (33) showing the internal positions that were substituted. All data were measured at 298 K in 100 mM KCl.
