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. 2008 Sep 2;295(5):E1038–E1046. doi: 10.1152/ajpendo.00061.2008

Fig. 4.

Fig. 4.

Hyperinsulinemic-euglycemic clamp was performed in 5-h-fasted wild-type (n = 8) and GM-CSF knockout mice (n = 12) on a HFD. A: basal and clamp insulin levels. B: glucose infusion rate during the final 30 min of the clamp. C: glucose clearance during the final 30 min of the clamp. Glucose clearance was significantly greater at baseline and during the end of the clamp in the GM-CSF knockout mice. D: endogenous glucose production at baseline and during the last 30 min of the 2-h clamp was significantly greater in GM-CSF knockout mice. E and F: glycolytic rate was significantly greater (E) and glucose storage was significantly lower (F) at the end of the clamp in GM-CSF knockout mice. G: insulin sensitivity to glucose calculated via the glucose infusion rate (GIR) divided by insulin levels was significantly greater in GM-CSF knockout mice. *P < 0.05, wild-type mice vs. GM-CSF knockout mice.