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The role of the FXR:SHP cascade in mediating the effect of β-Klotho on ASBT. The effect of siβ-Klotho on the ASBT promoter in CT-26 cells is abrogated when the liver receptor homolog (LRH)-1 cis-element is mutated (LRHμ) and when the effects of SHP and FXR are obviated by siRNA (siSHP or siFXR) or by a dominant-negative FXR construct (dnFXR).
