Fig. 6.

Effect of intraperitoneal FGF-19 on mouse ASBT. A: Ileum. FGF-19 treatment (lanes 1 to 4) relative to vehicle injection as a control (lanes 5 to 8) led to an induction of FXR and SHP protein expression and a repression of ASBT expression. Equivalent loading is demonstrated by the signal for actin. B: Gallbladder. 4 separate gallbladder samples were pooled with vehicle (V) and FGF-19 treatment (F). FXR and SHP protein expression was induced, whereas ASBT protein expression was inhibited. Equivalent loading is demonstrated by the signal for actin.