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. 2008 Sep 4;295(5):G996–G1003. doi: 10.1152/ajpgi.90343.2008

Fig. 8.

Fig. 8.

Model for the effect of β-Klotho and FGF-19 in enterocytes. β-Klotho is found on the cellular membrane and signals by unknown pathways to activate the FXR. FXR, in turn, enhances the expression of the SHP, which, in turn, inactivates the retinoic acid receptor (RAR), yielding a net result of diminished expression of the ASBT. FXR also enhances the expression of FGF-19 (◊); FGF-19 is secreted by the enterocyte and has paracrine effects on hepatocytes and/or cholangiocytes (not shown), whereas there are local autocrine effects on enterocytes. FGF-19 binding to the FGFR4 also leads to inhibition of ASBT expression by presently unidentified mechanisms.